[Heritability of bipolar affective disorder--family study].
2011
Background/Aim. Bipolar affective disorder is mental disorder with polygenic
type of heredity. Heritability - relation between genetic and environmental
variance is used to estimate the level of influence of genetic variance to
phenotype variance. Study results show decreasing trend in the value of
heritability of bipolar affective disorder, thus indicating that this
disorder is a complex behavioral threshold characteristic. Therefore, the aim
of this study was to estimate the contribution of genetic variance to
phenotype variance of bipolar affective disorder, i.e. to estimate
heritability of this disorder. Methods. By the use of a questionnaire, 80
patients with over crossed threshold for bipolar affective disorder were
asked for functional information about the members of their families
belonging to the first degree of relation (fathers, mothers and full- sibs).
By using ”Applet for calculating heritability for threshold traits
(disease)“, and regression analysis, heritability of bipolar affective
disorder as well as its statistical significance, were estimated (χ2 test).
Results. Heritability and relationship of genetic and environmental variance
of bipolar affective disorder is 0.2 with statistically significant
difference from zero (p < 0.001). Conclusion. The estimated contribution of
genetic variance to phenotype variance of bipolar affective disorder is low
being 20%, while the contribution of environmental variance is 80%. This
result contributes to the understanding of bipolar affective disorder as a
complex behavioral threshold trait.
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