A Cluster Model of Temperament as an Indicator of Antidepressant Response and Symptom Severity in Major Depression

Objective Not enough is known about which patients suffering from major depressive disorder benefit from antidepressant drug treatment. Individual temperament is relatively stable over a person's lifespan and is thought to be largely biologically predefined. We assessed how temperament profiles are related to depression and predict the efficacy of antidepressant treatment.