Inhibitory Effects of Pravastatin, a Competitive Inhibitor of Hydroxymethylglutaryl Coenzyme A Reductase, on Cholesterol Gallstone Formation in Prairie Dogs

Susumu Tazuma,Sumie Hatsushika,Naoki Aihara,Sagawa H,Gunji Yamashita,Masatoshi Sasaki,Sasaki H,Shigeki Mizuno,Seishi Tao,Goro Kajiyama

Inhibitory Effects of Pravastatin, a Competitive Inhibitor of Hydroxymethylglutaryl Coenzyme A Reductase, on Cholesterol Gallstone Formation in Prairie Dogs

1992

Susumu Tazuma
Sumie Hatsushika
Naoki Aihara
Sagawa H
Gunji Yamashita
Masatoshi Sasaki
Sasaki H
Shigeki Mizuno
Seishi Tao
Goro Kajiyama

The effects of pravastatin on cholesterol gallstone formation were determined in prairie dogs. We fed 10 prairie dogs 1 % cholesterol with or without 0.05% (w/w) pravastatin (n = 5, each) for 4 weeks.

Keywords:

Pravastatin
Reductase
Endocrinology
Cholesterol
Prairie dog
Internal medicine
Coenzyme A
Biology
Diabetes mellitus
Biological activity
Medicine
Fissipedia

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