Immune-enhancing activities of chondroitin sulfate in murine macrophage RAW 264.7 cells

Abstract As a representative sulfated glycosaminoglycan (GAG), chondroitin sulfate (CS) has been reported playing vital roles in the immune response in vivo and in vitro. However, limited information is available about their immune-enhancing activity. This study was to achieve more precise understandings about the immuno-stimulating activity of CS. In in vitro experiments, CS was found to significantly promote the pinocytic, phagocytic activity and ROS production of RAW264.7 cells at the dose range of 100–1000 μg/mL compared with the untreated group ( p