The interaction of lipoic acid and its metabolites with aspartate and alanine aminotransferases in a multienzyme complex from rat liver and brain mitochondria

: It is shown that lipoic acid and its metabolites--lipoamide and 4,6-dithiohexanoic acid can interact and inhibit the mitochondrial aspartate- and alanine-aminotransferase activities. This effect is much more pronounced in the case of multienzyme complexes--metabolon.