COMPARISON STUDY OF VITAMIN-B12 FOR ITS EFFICACY AND BIOAVAILABILITY OF VARIOUS FORMULATIONS IN THE TREATMENT OF PERNICIOUS ANEMIA

VitaminB 12 helps your body to use fat and carbohydrates for energy and makes new protein. It is also important for normal blood, cells, and nerves. Most people get enough vitaminB 12 in their diet, but a deficiency may occur in certain health conditions (e. g., poor nutrition, stomach/intestinal problems, infection, cancer). Serious VitaminB 12 deficiency results in anemia and nerve damage if left untreated. VitaminB 12 deficiency usually treated by parenteral and oral dosage forms, but these routes of administration is associated with absorption and compliance issue. More recently, it has been demonstrated that the function of this missing intrinsic factor is to aid the absorption of Vitamin B 12 and deficiency termed as pernicious anemia. Pernicious anemia may be satisfactorily treated by parenteral administration of the extrinsic factor, Vitamin B 12 is only slightly absorbed when given by mouth to patients with pernicious anemia, but a hematological response may be obtained if relatively large doses are given by this route. The objective of this study was to compare the efficacy and safety profile of appropriate vitamin B 12 formulation in the treatment of pernicious anemia.