Basic InvestigationAngiotensin II Increases the Expression of (Pro)Renin Receptor During Low-Salt Conditions

Background Evidence indicates that chronic angiotensin II (Angll) infusion increases (pro)renin receptor ((P)RR) expression in renal inner medullary collecting duct (IMCD) cells. Recently, it has been shown that renal (P)RR expression is augmented during a low-salt (LS) diet. However, the role of Angll in mediating the stimulation of (P) RR during LS conditions is unknown. We hypothesized that Angll mediates the increased expression of (P)RR during low-salt conditions in IMCDs.