Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand

Mohanraj Krishnan,Tanya J. Major,Ruth Topless,Ofa Dewes,Lennex Yu,John M. D. Thompson,Lesley M. E. McCowan,Janak de Zoysa,Lisa K. Stamp,Nicola Dalbeth,Jennie Harré Hindmarsh,Nuku Rapana,Ranjan Deka,Winston W. H. Eng,Daniel E. Weeks,Ryan L. Minster,Stephen T. McGarvey,Satupaitea Viali,Take Naseri,Muagututia S. Reupena,Phillip Wilcox,David R. Grattan,Peter R. Shepherd,Andrew N. Shelling,Rinki Murphy,Tony R. Merriman

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand

2018

Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations of Samoa and American Samoa. Our aim was to test rs373863828 for associations with BMI and the odds of type 2 diabetes, gout and chronic kidney disease (CKD) in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.

Keywords:

Internal medicine
Endocrinology
Gout
Obesity
Demography
Samoan
Biology
Kidney disease
Diabetes mellitus
Allele
Aotearoa
Type 2 diabetes
Waist
Logistic regression

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