2,4,5-trisubstituted imidazoles : Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

Sepehr Sarshar,Chengzhi Zhang,Edmund J. Moran,Sonja Krane,Jennifer C. Rodarte,Khalid D. Benbatoul,Ross Dixon,Adnan Mjalli

2,4,5-trisubstituted imidazoles : Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

2000

Sepehr Sarshar
Chengzhi Zhang
Edmund J. Moran
Sonja Krane
Jennifer C. Rodarte
Khalid D. Benbatoul
Ross Dixon
Adnan Mjalli

Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.

Keywords:

Organic chemistry
Biochemistry
Chemistry
Multiple drug resistance
P-glycoprotein
liquid phase
Chemical synthesis
In vivo
Cell culture
tumor cells
In vitro

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations