The hemopexin gene maps to the same location as the β-globin gene cluster on human chromosome 11 ☆

Abstract Using human hemopexin cDNA clones isolated from λgt11 cDNA library as probes, we have carried out Southern blot analysis of a series of human-Chinese hamster somatic cell hybrids containing different combinations of human chromosomes. Synteny analysis revealed 100% concordance between the hemopexin gene and human chromosome 11. In situ hybridization of 3 H-labeled hemopexin cDNA to metaphase chromosomes prepared from human lymphocytes further localized the gene to the region p15.4–p15.5, the same location as the β-globin gene cluster.