A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors

We report a novel 18 F-labeling method for the preparation of 18 F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18 F-labeled potential PET radiotracers of σ receptors for initial biological evaluations. 1 Introduction 2 Design and Synthesis of Novel [ 19 F]-3 and [ 19 F]-3′ 3 Radiosynthesis of Novel [ 18 F]-3 and [ 18 F]-3′ 4 In vivo Uptake and Pharmacokinetics of [ 18 F]-3 and [ 18 F]-3′ 5 Conclusion