Efficacy of levofloxacin 500 mg for middle ear diseases

: We examined the cases that prescribed levofloxacin (LVFX) 500mg for middle ear diseases in our hospital. LVFX 500mg was prescribed in 18 cases (7 male, 11 female, 24-81 years old). LVFX was mainly used for the following clinical conditions, 1) otitis media with granulation proliferation: 3 cases, 2) infection to an artificial materials : 5 cases, 3) treatment for or prevention against the inflammation of the inner ear: 4 cases. Three of eighteen cases were ineffective by LVFX treatment. Bacteriological examination indicated LVFX-resistant MRSA or Pseudomonas aeruginosa were isolated in these three cases.