International validation of an IGF-CTP scoring system for assessing hepatic reserve in hepatocellular carcinoma.

e15140 Background: The Child-Turcotte-Pugh score (CTP) is the standard tool for assessment of hepatic reserve in hepatocellular carcinoma (HCC), although it has several limitations. Recently, we reported that integrating plasma insulin-like growth factor-1 (IGF-1) level into the CTP score, creating the IGF-CTP (Kaseb-Morris) score, was associated with better patient risk stratification as compared to CTP score in two independent cohorts (training and validation) from the U.S. Our current study aimed to internationally validate the IGF-CTP score in patients who have different demographics, geographical location, and HCC risk factors. Methods: We prospectively recruited 100 Egyptian patients and their blood samples for IGF-1 analysis. We calculated their IGF-CTP scores and compared them to CTP score. The log-rank test was used to detect statistical significance. Harrell's C-index was used to compare the prognostic significance of the two scoring systems. Finally, we compared our results with the previous pu...