Expression and clinical significance of Survivin and Runx3 in gastric carcinoma

Objective:To study the expression and clinical significance of Survivin and Runx3 in gastric carcinoma tissue.Methods:The expressions of Survivin and Runx3 were detected by SP immunohistochemical technique in 52 cases of gastric carcinoma and analyze the relationship between the expression of Survivin,Runx3 and the clinicopathological character of samples.Results:The expression rate of Runx3 in gastric cancer was low(53.8%),and reduced with the increased invasive depth and occurrence of lymphatic metastasis,long-distance metastasis and clinical stages(P0.05).The expression rate of Survivin in gastric cancer was high(75.9%),and elevated with the increased invasive depth,occurrence of lymphatic metastasis and clinical stages(P0.05).Conclusion:The over-expression of Survivin and low-expression of Runx3 may play a role in the pathogenesis of gastric carcinoma,combined detection would be of benefit in selecting chemotherapeutic agents and evaluating prognosis in gastric carcinoma.