AB0555 Amount of Proteinuria Is Risk of Flare from Bvas Remission among Microscopic Polyangiitis Patients in Japan

Background Microscopic polyangiitis (MPA) is a common form of ANCA associated vasculitis in Japan. Renal involvement is frequent in MPA and an important factor with respect to therapeutic methods and outcomes. Objectives To determine the association between renal characteristics at diagnosis and the relapse. Methods A retrospective review was conducted in 28 patients who were newly diagnosed as MPA. (January 2007 to August 2015) Baseline characteristics are collected include urine profile and renal pathology. The primary endpoint is the first flare. Disease flare is defined an increase in at least one major Birmingham vasculitis activity score (BVAS) items. Furthermore, analysis on other outcomes, such as end stage renal failure, induction of hemodialysis and death has been conducted. Results Of the 28 patients with MPA, all patients had renal vasculitis. 18 achieved BVAS remission, and relapse occurred among 5 patients (19.2%). Cox multivariate analysis showed that amount of proteinuria on admission was a predictor of relapse (HR 4.2; 95% CI, 0.13–10.5). In renal biopsy, those relapsed five cases tend to have more intensive glomerulonephritis, according to the European Vasculitis Study Group (EUVAS) classification, though no statistical significance was performed. Conclusions Amount of proteinuria is a risk factor for relapse in MPA. References Suppiah R et al. A cross- sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis. Rheumatology. 2011;50: 899–905 Tarzi, R. M. et al. Issues in trial design for ANCA-associated and large-vessel vasculitis. Nature Review Rheumatology. 2014;10: 502–510 EBerden AE et al. Histopathological classification of ANCA-associated glomerulonephritis. Journal of American Society of Nephrology. 2010;10:1628–36 Disclosure of Interest None declared