Glutathione Metabolism: An Achilles’ Heel of ARID1A-Deficient Tumors

In this issue of Cancer Cell , Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A -inactivating mutations.