A Predictive Model For Cognitive Impairment In Individual Patient With Diabetes Mellitus (P4.195)

OBJECTIVE: To develop a simple predictive model which will allow us to determine, whether an individual patient has a greater risk of cognitive impairment and need to be further cognitive evaluated. BACKGROUND: Patients with DM have higher risk of cognitive impairment and dementia. DESIGN/METHODS: Three hundered patients were included (283 DM type 2, 17 DM type 1, 138 women). Cognitive status was evaluated using Clock Drawing Test. Patients who scored 3 out of 4 points or less were considered cognitive impaired. A predictive model using binary logistic regression was developed. In the model we included age, gender, duration of DM, level of education and presence of chronic limb pain. RESULTS: Mean age was 64.2 years (SD 10.5). Mean duration of DM was 12.5 years (SD 9). Majority of patients had 12 years of education (61.8%), 24.6% had 8 years or less and 13.6% had 14 to 18 years. Mean Clock Drawing Test score was 2.9 (SD 1.2). Less than half of patients (46%) scored 4/4 points. Patients without cognitive impairment were younger (61.1 years [SD 10.4] vs. 66.8 [9.9] years; p<0.001) and had shorter DM duration (10.9 [7.7] years vs. 13.9 [9.8] years; p=0,005). Statistically significant variables in logistic model (constant B:-4.96) were: gender (B: 0.6), age (B: 0.05), duration of DM (B: 0.03), primary education (8 years or less) (B: 0.91) and presence of chronic limb pain (B: 0.97). I.e. a chance for cognitive impairment in 70 year old man with primary education (8 years), 10 year DM duration and chronic limb pain is 71%. CONCLUSIONS: Cognitive impairment is common among DM patients in our group (54%). Two important mile stones are age of 61 years and DM duration of 11 years or more. Particularly vulnerable are older, low educated men, with long term diabetes and chronic limb pain. Disclosure: Dr. Rakusa has received personal compensation for activities with Pfizer Inc. as a speaker. Dr. Rakusa has nothing to disclose. Dr. Cokolic has nothing to disclose.