Glycyrrhetinic acid derivative and application thereof as antitumor medicament

The invention relates to the field of medicaments, in particular to glycyrrhetinic acid derivatives capable of releasing gas signaling molecule hydrogen sulfide, pharmaceutically acceptable salts thereof, preparation methods thereof, a medicinal composition containing the derivatives and antitumor functions thereof, in particular to application thereof to the preparation of antitumor medicaments.The glycyrrhetinic acid derivatives are obtained by coupling glycyrrhetinic acid, a glycyrrhetinic acid derivative and a hydrogen sulfide donor through an ester bond or an amide bond. The invention initially provides the glycyrrhetinic acid derivatives capable of releasing gas signaling molecule H2S. The antitumor medicaments with higher activity are obtained by modifying the glycyrrhetinic acid.