The Novel Use of Postbiotics of TYCA06/AP-32/CP-9 in the Amelioration of Atopic Dermatitis and Improvement of Skin Care - A Clinical Study

The development of human society has created many synthetic materials for better convenience; however, these innovated products usually produce unnatural side chemicals in the environment. The skin is the first barrier of defense against pathogens and toxicants, so the health of skin is important not only on facial appearance but also on physical health. Many people live a busy life and the habit of refined diet and over-cleaning does not improve the quality of life. In contrary, the overuse of detergents and antibiotics may cause skin dysbiosis, and result in a sensitive skin, aging skin, or, moreover, atopic dermatitis. In this study, the postbiotic blend of three probiotic strains, TYCA06/AP-32/CP-9 (TAC), displayed the growth inhibition against Staphylococcus aureus, and the stimulation of the anti-inflammatory cytokine in vitro, such as transforming growth factor (TGF)-β and interleukin (IL)-10. This TAC formula enhanced the wound healing in keratinocytes HaCaT cell culture and increased moisture content on skin in vivo. The TAC formula was further incorporated into a cosmetic lotion, and the human clinical trial was carried out by applying this lotion on volunteers’ face or hand with atopic dermatitis (AD). The result showed the TAC lotion improved the moisture score, inflammation index, and brightening score of the skin. In addition, this TAC lotion also improved the wound repair of cracked skin in volunteers with AD. Moreover, this TAC lotion reduced the number of the speckle and wrinkles on facial skin. Taken together, this postbiotic blend of TAC has beneficial effects on skin health, and is able to ameliorate the red and itchy skin in AD patients.