Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

Jennifer Wessel,Timothy Majarian,Heather M. Highland,Sridharan Raghavan,Mindy D Szeto,Natalie R Hasbani,Paul S de Vries,Jennifer A. Brody,Chloé Sarnowski,Daniel DiCorpo,Xianyong Yin,Bertha Hidalgo,Xiuqing Guo,James A. Perry,Jeffrey R. OConnell,Samantha Lent,May E. Montasser,Brian E. Cade,Deepti Jain,Heming Wang,Peitao Wu,Sílvia Bonàs-Guarch,Ricardo DOliveira Albanus,Aaron Leong,Irene Miguel-Escalada,Arushi Varshney,TOPMed Anthropometry,Diamante,Gregory L. Kinney,Lisa R. Yanek,Leslie A. Lange,Marcio Almeida,Juan M. Peralta,Stella Aslibekyan,Abigail S. Baldridge,Alain G. Bertoni,Lawrence F. Bielak,Donald W. Bowden,Chung-Shiuan Chen,Yii-Der Ida Chen,Seung Hoan Choi,Won Jung Choi,Dawood Darbar,James S. Floyd,Barry I. Freedman,Mark O. Goodarzi,Marguerite R. Irvin,Rita R. Kalyani,Tanika N. Kelly,Seonwook Lee,Ching-Ti Liu,Douglas Loesch,JoAnn E. Manson,Rami Nassir,Nicholette D. Palmer,James S. Pankow,Laura J. Rasmussen-Torvik,Alex P. Reiner,Elizabeth Selvin,Aladdin H. Shadyab,Jennifer A. Smith,Daniel E. Weeks,Lu-Chen Weng,Huichun Xu,Jie Yao,Zachary Yoneda,Wei Zhao,Jorge Ferrer,Anubha Mahajan,Mark I. McCarthy,Stephen Parker,Alvaro Alonso,Donna K. Arnett,John Blangero,Eric Boerwinkle,Michael H. Cho,Adolfo Correa,L. Adrienne Cupples,Joanne E. Curran,Ravindranath Duggirala,Patrick T. Ellinor,Jiang He,Susan R. Heckbert,Sharon L.R. Kardia,Ryan W. Kim,Charles Kooperberg,Simin Liu,Steven A. Lubitz,Rasika A. Mathias,Stephen T. McGarvey,Braxton D. Mitchell,Alanna C. Morrison,Patricia A Peyser,Bruce M. Psaty,Susan Redline,Dan M. Roden,M. Benjamin Shoemaker,Nicholas L. Smith,Kent D. Taylor,Ramachandran S. Vasan,Karine A. Viaud-Martinez,Jose C. Florez,James G. Wilson,Robert Sladek,Josée Dupuis,S S Rich,Jerome I. Rotter,James B. Meigs,Alisa K. Manning

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

2020

Jennifer Wessel
Timothy Majarian
Heather M. Highland
Sridharan Raghavan
Mindy D Szeto
Natalie R Hasbani
Paul S de Vries
Jennifer A. Brody
Chloé Sarnowski
Daniel DiCorpo
Xianyong Yin
Bertha Hidalgo
Xiuqing Guo
James A. Perry
Jeffrey R. OConnell
Samantha Lent
May E. Montasser
Brian E. Cade
Deepti Jain
Heming Wang
Peitao Wu
Sílvia Bonàs-Guarch
Ricardo DOliveira Albanus
Aaron Leong
Irene Miguel-Escalada
Arushi Varshney
TOPMed Anthropometry
Diamante
Gregory L. Kinney
Lisa R. Yanek
Leslie A. Lange
Marcio Almeida
Juan M. Peralta
Stella Aslibekyan
Abigail S. Baldridge
Alain G. Bertoni
Lawrence F. Bielak
Donald W. Bowden
Chung-Shiuan Chen
Yii-Der Ida Chen
Seung Hoan Choi
Won Jung Choi
Dawood Darbar
James S. Floyd
Barry I. Freedman
Mark O. Goodarzi
Marguerite R. Irvin
Rita R. Kalyani
Tanika N. Kelly
Seonwook Lee
Ching-Ti Liu
Douglas Loesch
JoAnn E. Manson
Rami Nassir
Nicholette D. Palmer
James S. Pankow
Laura J. Rasmussen-Torvik
Alex P. Reiner
Elizabeth Selvin
Aladdin H. Shadyab
Jennifer A. Smith
Daniel E. Weeks
Lu-Chen Weng
Huichun Xu
Jie Yao
Zachary Yoneda
Wei Zhao
Jorge Ferrer
Anubha Mahajan
Mark I. McCarthy
Stephen Parker
Alvaro Alonso
Donna K. Arnett
John Blangero
Eric Boerwinkle
Michael H. Cho
Adolfo Correa
L. Adrienne Cupples
Joanne E. Curran
Ravindranath Duggirala
Patrick T. Ellinor
Jiang He
Susan R. Heckbert
Sharon L.R. Kardia
Ryan W. Kim
Charles Kooperberg
Simin Liu
Steven A. Lubitz
Rasika A. Mathias
Stephen T. McGarvey
Braxton D. Mitchell
Alanna C. Morrison
Patricia A Peyser
Bruce M. Psaty
Susan Redline
Dan M. Roden
M. Benjamin Shoemaker
Nicholas L. Smith
Kent D. Taylor
Ramachandran S. Vasan
Karine A. Viaud-Martinez
Jose C. Florez
James G. Wilson
Robert Sladek
Josée Dupuis
S S Rich
Jerome I. Rotter
James B. Meigs
Alisa K. Manning

Type 2 diabetes is increasing in all ancestry groups. Part of its genetic basis may reside among the rare (minor allele frequency

Keywords:

Heritability
Genetics
Omics
Whole genome sequencing
Minor allele frequency
Precision medicine
Type 2 diabetes
Biology

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