3,4-disubstituted(1H-pyrazole[3,4-b]pyridine) compound and use thereof

2013 
The invention mainly relates to a 3,4-disubstituted(1H-pyrazole[3,4-b]pyridine) compound and a use thereof. The 3,4-disubstituted(1H-pyrazole[3,4-b]pyridine) compound is a compound represented by the formula I or a pharmaceutically acceptable salt thereof (referring to the description or claims for details). The compound provided by the invention shows a stronger inhibitory activity on tyrosine kinase (including c-Kit, PDGFR[alpha], VEGFR2 and FGFR1) related to occurrence and development of four tumors. The compound is indicated to be used as a multi-target kinase inhibitor, and is developed into a targeted anti-tumor drug in allusion to acute granulocytic leukemia and solid tumors.
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