Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients

Paola Parrella,Raffaela Barbano,Barbara Pasculli,Andrea Fontana,Massimiliano Copetti,Vanna Maria Valori,Maria Luana Poeta,Giuseppe Perrone,Daniela Righi,Marina Castelvetere,Michelina Coco,Teresa Balsamo,Maria Morritti,Fabio Pellegrini,Andrea Onetti Muda,Evaristo Maiello,Roberto Murgo,Vito Michele Fazio

Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients

2014

Paola Parrella
Raffaela Barbano
Barbara Pasculli
Andrea Fontana
Massimiliano Copetti
Vanna Maria Valori
Maria Luana Poeta
Giuseppe Perrone
Daniela Righi
Marina Castelvetere
Michelina Coco
Teresa Balsamo
Maria Morritti
Fabio Pellegrini
Andrea Onetti Muda
Evaristo Maiello
Roberto Murgo
Vito Michele Fazio

Background MicroRNA-10b (miR-10b) has a prominent role in regulating tumor invasion and metastasis by targeting the HOXD10 transcriptional repressor and has been found up-regulated in several tumor types.

Keywords:

Cancer research
Prospective cohort study
Breast cancer
Proportional hazards model
microRNA
Survival analysis
Predictive value of tests
Metastasis
HOXD10
Oncology
Internal medicine
Medicine
Nottingham Prognostic Index
RNA integrity number

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