Value of EGD for gastric cancer surveillance in patients with hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome (LS).

1522Background: Gastric cancer (GC) is the second most common non-gynecologic malignancy in patients with LS. Due to an absence of prospective randomized data, the value of esophago-gastro-duodenoscopy (EGD) for GC surveillance in LS patients remains a controversial issue. According to German guidelines regular EGDs beginning at the age of 35 are recommended for LS patients. The focus of this study was to evaluate the effectiveness of EGD as an instrument for early GC detection. Methods: Data of HNPCC and LS patients diagnosed with GC was retrieved from the German Consortium for Familial Intestinal Cancer Registry. Individuals from 3 groups were included: pathogenic germline mismatch repair gene mutation carriers (n = 47), untested patients from families with known germline mutations (putative carriers; n = 8) and individuals fulfilling at least the revised Bethesda criteria without a mutation but with microsatellite instability (MSI group; n = 47). Statistics were calculated using Fisher’s exact test. Re...