Resistance-Modifying Agents. Part 7. 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that Inhibit Nucleoside Transport in the Presence of α1-Acid Glycoprotein (AGP).

Abstract The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to α1-acid glycoprotein, is reported.