Postoperatif Radyoterapi İle Eş Zamanli Kapesitabin Uygulanan Lokal İleri Evre Rektum Kanserli Olgularda Etkinlik ve Tolerabilite Değerlendirilmesi

The purpose of this study was to evaluate the efficacy and the toxicity of concomitant chemoradiotherapy (CRT) with capecitabine in cases with locally advanced rectal cancer. 26 cases with stage II-III rectal adenocarcinoma, treated with postoperative CRT with capecitabine at Uludag University Faculty of Medicine Radiotherapy Center, between March 2004-January 2007, were evaluated retrospectively. The radiotherapy was delivered with a boost dose of 50.4-54 Gray (Gy) totally and capecitabine was given median 1650 mg/m²/day (range, 13001650). The median 2- year overall survival (OS) was 80%, and during the median follow-up time of 19 months (range, 1-30) there was no locoregional recurrence. Grade 3 leucopenia and diarrhea were observed in one (4%) and two (8%) cases, respectively. Although the insufficiency of follow-up time and the number of cases, we concluded that the concomitant postoperative chemoradiotherapy with capecitabine may be an effective and tolerabl treatment in locally advanced rectal cancer.