Famotidine, the new antiulcero-genic agent, a potent ligand for metal ions

Abstract Potentiometric, polarographic, and spectroscopic results obtained for Cu 2+ and Ni 2+ -famotidine systems clearly indicated that this anti-ulcerogenic drug is a very potent chelating agent able to coordinate cupric ion that was at pH below 2. This drug exhibits excellent histamine H 2 receptor blocking effects and its effective coordination to metal ions may have significant biological implications. Famotidine is found to be a very effective ligand for Ni 2+ ions also.