Humoral factors in serum of rats with chronic heart failure induce cardiomyocyte hypertrophy and reduce viability.

Myocardial infarction (MI) is one of the leading causes of global mortality. Over the last decade, acute MI mortality has significantly decreased; however, fatal heart failure remains a common complication for post-MI survivors.[1][1] Lack of oxygen due to MI causes cardiac tissue necrosis and, as a