HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

Claire Jacob,Carlos N Christen,Jorge A. Pereira,Christian Somandin,Arianna Baggiolini,Pirmin Lötscher,Murat Özçelik,Nicolas Tricaud,Dies Meijer,Teppei Yamaguchi,Patrick Matthias,Ueli Suter

HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

2011

Claire Jacob
Carlos N Christen
Jorge A. Pereira
Christian Somandin
Arianna Baggiolini
Pirmin Lötscher
Murat Özçelik
Nicolas Tricaud
Dies Meijer
Teppei Yamaguchi
Patrick Matthias
Ueli Suter

This work shows that HDAC1 and HDAC2 control Schwann cell differentiation and peripheral myelination: HDAC1 maintains Schwann cell survival by downregulating active β-catenin and HDAC2 induces myelination transcription programming.

Keywords:

Neuroscience
HDAC1
Transcription (biology)
Histone deacetylase 2
Peripheral nervous system
Schwann cell
Histone deacetylase
Schwann cell differentiation
Biology
Transcriptional regulation

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