Colitis locus on chromosome 2 impacting the severity of early‐onset disease in mice deficient in GPX1 and GPX2

Background Genetic background has a profound effect on inflammatory bowel disease. The Gpx1 and Gpx2 double knockout (GPX1/2-DKO) mice on a mixed C57BL/6 (B6) and 129S1/SvimJ (129) background had spontaneous ileocolitis. The DKO mice on a B6 background had mild ileocolitis. We characterized the 129 DKO mice to identify a genetic locus affecting disease severity.