Studies with Brugia pahangi. 18. Anthelmintic effects of stibocaptate.

Stibocaptate ( Astiban , Hoffman - La Roche) killed third stage larvae of Brugia pahangi in vitro at 50 p.p.m. but had no effect on microfilariae at 1 × 10 4 p.p.m. No larvae developed in infected mosquitoes fed 1% stibocaptate in 10% sucrose. It was neither micro-nor macrofilaricidal in neither jirds or cats but did affect embryogenesis.