Barberry Administration and Pro-Oxidant-Antioxidant Balance in Patients With Metabolic Syndrome

Background: Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant-antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD. Objectives: This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome. Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention. Results: There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01). Conclusions: Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.