Thrombocytopenia post Transcatheter Aortic Valve Insertion: Clinical and Prognostic Significance

ABSTRACTBackground: Transcatheter aortic valve insertion (TAVI) has revolutionized the management of aortic stenosis in patients at high surgical risk. Major thrombocytopenia has previously been assessed as a predictor of short- and long-term mortality. This study aimed at identifying the predictors and prognostic value of major thrombocytopenia post TAVI.Methods: Patients who underwent TAVI at a metropolitan quaternary referral centre in Australia over an 8-year period were included. Primary outcomes included 30-day and 1-year mortality. Secondary outcomes included Bleeding Academic Research Consortium (BARC) minor, major and life-threatening bleeding. Baseline characteristics and platelet counts were collected retrospectively.Results: A total of 331 consecutive patients were included in the analysis. The only predictor of major thrombocytopenia was pre-procedural platelet count (p < 0.01). Patients who had major thrombocytopenia post TAVI had increased 30-day mortality (OR 4.37, 95% CI 1.35–14.16, p = 0...