Abstract 12827: Serum Levels of High-Density Lipoprotein-Associated Paraoxonase-1 Predict Recurrent Cardiovascular Events After Drug-Eluting Stent Implantation in Patients With Stable Angina Pectoris

Background: It is well established there is an inverse relationship between high-density lipoprotein (HDL) cholesterol and the risk for coronary artery disease, with its antioxidant properties attributed mainly to the HDL-bound enzyme, paraoxonase-1 (PON-1). We reported that plasma levels of myeloperoxidase, a pro-oxidant enzyme released from activated neutrophils that alters the atheroprotective function of HDL to a dysfunctional form, has a significant inverse correlation with PON-1 levels, especially in female patients with stable angina pectoris (SAP) (Atherosclerosis, 231, 308-314, 2013). Drug-eluting stents (DES) reduce the rate of restenosis, although recurrent angina and repeat revascularization remain major limitations. We investigated whether PON-1 levels predict cardiovascular events in patients with SAP undergoing DES implantation. Methods: Serum PON-1 concentration and activity were measured on admission in 191 SAP patients and 99 control subjects. We also assessed the prognostic significance...