The Natural Antimicrobial Chromogranins/Secretogranins- Derived Peptides – Production, Lytic Activity and Processing by Bacterial Proteases

Multidrug-resistant organisms, such as methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant enterococci (VRE) have important infection control implications in all healthcare stings. Multidrug antibiotic resistance is a worldwide crucial health problem and the production of new potent antibiotics, acting alone or in combination is urgent. In addition, a major factor in the emergence of antibiotic resistant organisms is the overuse of antibiotics in the hospital or the community. To overcome this abuse, numerous efforts are undertaken to reduce antibiotics prescription and/or promote synergistic effects by others molecules.