Findings of 123I-MIBG Cardiac Scintigraphy: Parkinson’s Disease and Related Disorders and Others (RBD, Cardiac Diseases, DM, etc.)

A wide range of autonomic dysfunctions has been described in Parkinson’s disease (PD). Since its description, myocardial iodine-123-meta-iodobenzylguanidine (123I-MIBG) cardiac scintigraphy has attracted attention as a useful tool for the diagnosis of PD. There is a general agreement that the H/M ratio in 123I-MIBG cardiac scintigraphy is significantly low in both early and delayed images of PD patients. Reduced cardiac MIBG uptake has been reported in not only patients with PD but also in dementia with Lewy bodies (DLB), rapid eye movement behavior disorder (RBD), and pure autonomic failure (PAF). In this regard, 123I-MIBG cardiac scintigraphy can be useful for differentiating Lewy body disorders from other parkinsonian syndromes and dementias.