Medicines in pharmaceutical form “solution for injection” and the injection of drugs: advantages and limitations

The literature review shows that today any substance, and hence any drug, can be in such physical states as solid, liquid, gas and plasma. The classification of pharmaceutical forms of drugs, from which it follows that presently the drugs are produced in solid, liquid, soft and gaseous “dosage forms”. It is shown that the modern quality standards of drugs do not guarantee the presence of a single aggregate physical properties of all drugs produced in the same dosage forms. It is established that modern quality standards of drugs allow the production of drugs in the same pharmaceutical forms, but with different concentrations of all ingredients and with different physical and chemical properties. The ranges of concentration values of the dissolved ingredients and indicators of acid (alkaline) and osmotic activity of high-quality drugs from different pharmacological groups produced by different pharmaceutical companies in the form of “Solutions for injection” are given. From the above examples, it follows that at present qualitative “Solutions for injections” have an acidity value in the range of pH 2-12 and an osmotic activity value in the range of 0-3900 mOsmol/l of water. In addition to this, it is shown that modern drugs prepared in the pharmaceutical form “Solutions for injection” and considered to be of high quality, have a concentration of dissolved ingredients in the range of 0.01-100 %. Therefore, almost all modern medicines produced in the dosage form “Solutions for injection” have different mechanical, physical, chemical and/or physico-chemical properties that can change their pharmacological activity. Examples are given of how different concentrations of ingredients and osmotic activity of certain drugs in the dosage form “Solutions for injections” affect the severity of their local action on tissues in the range from short-term inflammation of tissues to their necrosis. It is proved that modern “solutions for injections” do not guarantee the safety of local interaction with viable tissues of the human body. The technologies of improving the safety of injection of modern “Solutions for injection” and technology to prevent tissue necrosis with “wrong” injections of drugs (by accident, ignorance, ignorance, mistake) are listed.