Serenoa Serrulata Fruit Extract Can Relax Stretch Mark Myofibroblasts In Vitro and Improve Stretch Mark Appearance In Vivo

Stretch marks primarily result from the sudden stretch that occurs in case of unusual weight gain or pregnancy. As a result of the stretch, skin fibroblasts begin to express a specific protein, α-SMA, that confers them contractile properties. At the same time, fibroblast and loose most of their abilities to synthesize matrix macromolecules such as collagen. A fruit extract of Serenoa serrulata (Saw palmetto) was assessed in vitro for its ability to relax stretch mark-derived fibroblasts, increase collagen synthesis and increase elastin mRNA expression. A three month in vivo study was conducted to evaluate the ability of a cosmetic formula containing 3% of Serenoa serrulata fruit extract to improve stretch-marked skin appearance. Skin firmness and elasticity on the stretch marked area was significantly improved within 2 months as assessed by clinical evaluation. After 3 months of use, volunteers who applied the formula containing Serenoa serrulata fruit extract declared that their skin felt increasingly firm and elastic and that stretch marks were less visible. Serenoa serrulata showed interesting properties and could be used as ingredient in topical cosmetic preparations aimed at improving the feeling and appearance of stretch marks.