Unique Features of Dendritic Cells in IFN-γ Transgenic Mice: Relevance to Cancer Development and Therapeutic Implications

Abstract Although induction of interferon gamma (IFN-γ) and activation of antigen presenting dendritic cells (DCs) are two vital events during an immune response, the impact of endogenous IFN-γ on DC function has yet to be clarified. The phenotype and function of DCs isolated from mice with high (IFN-γ-transgenic mouse [Tg]) and undetectable levels of circulating IFN-γ (normal mice [NM]) were therefore compared. The capacity to stimulate allogenic (p in vivo.