Chemomodulatory Influence of Melatonin Rich Morus Alba L. on N-Methyl-N- Nitrosourea (NMU) Induced Mammary Carcinoma in Sprague-Dawley Rats

We show that Melatonin rich Morus alba Linn is a potent inhibitor of mammary carcinogenesis induced by N-methyl-N-nitrosourea (NMU) in Sprague Dawley rats. Rats were first treated with a single dose of NMU (50 mg/kg body weight) and then treated with Methanolic extract of Morus alba Linn (MMA) with different concentrations 300mg/kg and 500mg/kg body weight. MMA was highly effective in reducing tumor incidence, tumor volume, and average tumor burden, as well as extending tumor latency. The MMA was particularly effective; when compared to the NMU only group tumor-free at autopsy and significantly diminished tumor number and tumor burden. MMA at the dose of 300mg/kg is effective when compared to 500mg/kg body weight. Compared with the Melatonin (MEL) and standard Tamoxifen (TAM) MMA also shown equivalent activity in tumor latency, tumor burden and tumor volume and compared with NMU only group tumor latency, tumor burden and tumor volume decreased.