Proliferative disease treatment method using a homo-oligomerization inhibition of synoviolin

The present invention provides at least one therapeutic agent selected from the group consisting of proliferative diseases, neurological diseases and allergic diseases of inhibiting auto-ubiquitination of synoviolin. Further, the present invention is a candidate substance is brought into contact with a candidate substance to synoviolin evaluates whether inhibiting auto-ubiquitination of synoviolin, proliferative diseases a candidate substance that inhibited self ubiquitination of synoviolin, nervous system diseases and characterized by selecting as at least one therapeutic agent selected from the group consisting of allergic diseases, to provide a screening method for the therapeutic agent.