Inhibition by α-Amanitin of Simian Virus 40-Specific Ribonucleic Acid Synthesis in Nuclei of Infected Monkey Cells

Conditions affecting the synthesis of simian virus 40-specific ribonucleic acid (RNA) in nuclei isolated from lytically infected cells were investigated. Deoxyribonucleic acid-RNA hybridization results show that an α-amanitin-sensitive RNA polymerase activity is responsible for transcription of simian virus 40 deoxyribonucleic acid.