Апингалин снижает степень эндогенной интоксикации при отеке легких у крыс

The purpose of the study is to investigate the influence of exchange rate inhalation mixture based on propolis and royal jelly "Аpingalin" on the degree of endogenous intoxication in experimental pulmonary edema in rats. Blood, urine and histologic liver sections of 90 white male rats weighing 0.15 to 0.2 kg were studied. The animals were divided into groups: intact animals; control animals in which adrenal pulmonary edema was replicated; experience animals which first had pulmonary edema replicated and which then inhaled "Аpingalin" (10 days by 10 minutes). The intake of all types of biological material was carried out at the 11 th day after the beginning of the experiment. The degree of endogenous intoxication was assessed by the protein profile of the dried drop of blood serum. Kidneys functional activity was assessed by the concentration of middle molecules in plasma and urine of experimental animals. The effect of "Apingalin" on liver cells in pulmonary edema was studied by histological specimen and the quantity of total protein and fibrinogen in plasma. It was found out that at the adrenal experimental pulmonary edema in rats endogenous intoxication developed; it was revealed through the increase in the number of middle molecules on erythrocytes and in plasma, with its decrease in the urine, and in the change of the normal ratio between albumins and globulins in serum in comparison with intact animals; a morphological picture of the liver tissue was damaged (degeneration of hepatocytes). Course inhalation of the mixture based on propolis and royal jelly "Аpingalin" allowed to reduce the level of endogenous intoxication in alterative animals, which was shown through the decrease of overall toxicity of the blood (the decrease in the number of middle molecules on erythrocytes and in plasma, the normalization of the protein composition of serum), improvement of histology of the liver (the restoration of blood flow, expressed mitotic activity of the cells) and normalization of kidney function.