Immune-desert tumor microenvironment in SMARCA4-deficient thoracic sarcomas with limited efficacy of immune checkpoint inhibitors.

Justine Gantzer,Guillaume Davidson,Bujamin Hektor Vokshi,Noelle Weingertner,Antoine Bougoüin,Marco Moreira,Véronique Lindner,Guillaume Lacroix,Céline Mascaux,Marie-Pierre Chenard,Irwin Davidson,Jean-Emmanuel Kurtz,Catherine Sautès-Fridman,Wolf-Herman Fridman,Gabriel G. Malouf

Immune-desert tumor microenvironment in SMARCA4-deficient thoracic sarcomas with limited efficacy of immune checkpoint inhibitors.

2021

Justine Gantzer
Guillaume Davidson
Bujamin Hektor Vokshi
Noelle Weingertner
Antoine Bougoüin
Marco Moreira
Véronique Lindner
Guillaume Lacroix
Céline Mascaux
Marie-Pierre Chenard
Irwin Davidson
Jean-Emmanuel Kurtz
Catherine Sautès-Fridman
Wolf-Herman Fridman
Gabriel G. Malouf

11552Background: SMARCA4-deficient thoracic sarcomas (SDS) are rare and aggressive sarcomas characterized by inactivating SMARCA4 mutations, with no approved treatment to date. Previous data linkin...

Keywords:

Tumor microenvironment
Medicine
SMARCA4
Cancer research
Immune system
immune checkpoint inhibitors

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