Over expression of circulating miR-155 predicts prognosis in diffuse large B-cell lymphoma

Abstract Introduction The expression patterns of microRNAs in plasma are involved in potential biomarkers for several diseases. The goal of this study was to explore the expression level of miR-155 in diffuse large B-cell lymphoma (DLBCL) and its clinical significance. Materials and methods We used qRT-PCR to assess the peripheral blood plasma of 40 DLBCL patients for the expression of miRNA-155. The median of miR-155 expression divided the DLBCL patients into miR-155 low-expression (miR-155 low ) and miR-155 high-expression (miR-155 high ) groups. Results and discussion We found that plasma miR-155 expression was significantly up-regulated in patients with DLBCL (median expression value: 4.29, range: 1.52–27.86) compared to healthy individuals (median expression value: 2.14, range: 0.29–10.56, P