Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells.

Ashani Montgomery,Franklin Tam,Chris Gursche,Catherine Cheneval,Katrina Besler,Winnie Enns,Sukhbir Manku,Kevin Rey,Paul J. Hanson,Stefan Rose-John,Bruce M. McManus,Jonathan C. Choy

Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells.

2021

Ashani Montgomery
Franklin Tam
Chris Gursche
Catherine Cheneval
Katrina Besler
Winnie Enns
Sukhbir Manku
Kevin Rey
Paul J. Hanson
Stefan Rose-John
Bruce M. McManus
Jonathan C. Choy

IL-6 affects tissue reparative and inflammatory properties of vascular endothelial cells (ECs). This cytokine can signal to cells through classic and trans-signaling mechanisms, which are different...

Keywords:

CCL2
Chemistry
Inflammation
Growth factor
Endothelial stem cell
Interleukin 8
Cell biology
Cytokine
Cell signaling
Signal transduction

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