The combination latanoprost-timolol versus twice daily 0.50% timolol administration either associated or not with latanoprost: efficacy and tolerability in the primary open-angle glaucoma.

Aims: To evaluate the ocular hypotensive effects and tolerability of the once daily fixed combination latanoprost-timolol ver- sus twice daily 0.50% timolol associated or not with once daily latanoprost in patients suffering from Primary Open-Angle Glaucoma (POAG). Methods: We compared the effects of such a combination with those of 0.50% timolol alone twice daily in a group of 24 patients and with the effects of timolol 0.50% twice daily associ- ated with once daily latanoprost in a second group of 20 patients with a follow-up of 24 months. Results: In the first group of patients after one month the Intraocular Pressure (IOP) was