Enzymatic Resolution of Oxalate Esters of a Tertiary Alcohol Using Porcine Pancreatic Lipase.

Ian Brackenridge,Raymond McCague,Stanley M. Roberts,Nicholas J. Turner

Enzymatic Resolution of Oxalate Esters of a Tertiary Alcohol Using Porcine Pancreatic Lipase.

2010

Ian Brackenridge
Raymond McCague
Stanley M. Roberts
Nicholas J. Turner

The tertiary alcohol 5 has been resolved to 90% ee (42% yield) by hydrolysis of its oxalate 6b with porcine pancreatic lipase in pH 7 buffer containing 13%tert-butyl alcohol.

Keywords:

Pancreatic lipase
Bridged compounds
Oxalate
Enzyme
Alcohol
Chemistry
Organic chemistry

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