Design, synthesis and structure-activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists.

Abstract A series of zwitterionic spirocyclic compounds were synthesised. In vitro data revealed that these compounds were potent CCR1 antagonists. In particular, 2 , 4 , 11 and 20 inhibited CCR1 mediated chemotaxis of THP-1 cells in a functional assay.