Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

Ling Huang,Audrey Holtzinger,Ishaan Jagan,Michael BeGora,Ines Lohse,Nicholas Ngai,Cristina Nostro,Rennian Wang,Lakshmi Muthuswamy,Howard C. Crawford,C.H. Arrowsmith,Steve E. Kalloger,Daniel John Renouf,Ashton A. Connor,Sean Cleary,David F. Schaeffer,Michael H.A. Roehrl,Ming-Sound Tsao,Steven Gallinger,Gordon Keller,Senthil K. Muthuswamy

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

2015

Human pluripotent stem cells can be differentiated into exocrine pancreas progenitor organoids, allowing studies of development and pancreatic cancer modeling.

Keywords:

Exocrine pancreas
Induced pluripotent stem cell
Proto-Oncogene Proteins
Immunology
Drug
Pancreatic cancer
Progenitor
Pancreas
Pathology
Organoid
Medicine
Carcinoma

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