Association study between Protein Kinase C gamma gene polymorphism and major depressive disorder

Objective To explore the genetic association of PKCγgene rs3745406 polymorphism with maior depressive disorder(MDD)and their clinical pbenotypes. Methods A total of 453 Chinese Hall MDD patients with an initial episode were recruited from our hospital.The symptonmtic phenotypes of these cases were evaluated by HAMD.Polymerase chain reaction (PCR) and difeet sequencing analysis were used to detect the genotype of rs3745406.Associations of allele.genotype and quantitative character were analyzed using the UNPHASED software. Results (1) The distributions of genotypes in both study and control samples were in a Hardy-Weinberg equilibrium(X~2=1.46,P=0.25);(2)No significant allelic and genotypie association Was found in these samples(P>0.05);(3)Further analyses revealed a significant association between rs3745406 locus and HAMD suicidal phenotypes(X~2=4.746,P=0.0360). Conclusion The PKC,rs3745406 polymorphism is not significantly associated with MDD whereas it has a marked association with suicidal symptoms in MDD. Key words: Depressive disorder,major; Protein Kinase C; Polymorphism,single nucleetide; Heredity